Alzheimer's Disease Clinical Trial
Having memory problems or trouble thinking clearly?
If this sounds like you, or someone you know, please consider the EMERGE Study.
Having memory problems or trouble thinking clearly? If this sounds like you, or someone you know, please consider the EMERGE Study.
Active not recruiting Brooksville, FL, USA 34601
Lehigh Center for Clinical Research LLC
Active not recruiting 401 North 17th Street, Allentown, PA, USA 18104
Klinikum Altenburger Land GmbH
Active not recruiting Altenburg, Thueringen, DEU 04600
Alzheimer Research Center
Active not recruiting 2 Cronenburg, Amsterdam, NLD 1081 GM
Emory University Cognitive Neurology Clinic ADRC
Active not recruiting Atlanta, GA, USA 30329
JEM Research Institute
Active not recruiting Atlantis, FL, USA 33462
University of Colorado Denver
Active not recruiting 13001 East 17th Place, Aurora, CO, USA 80045
Details for the study
Treatments and/or Procedures
Key Inclusion Criteria: - Must meet all of the following clinical criteria for MCI due to AD or mild AD and must have: - A Clinical Dementia Rating (CDR)-Global Score of 0.5. - Objective evidence of cognitive impairment at screening - An MMSE score between 24 and 30 (inclusive) - Must have a positive amyloid Positron Emission Tomography (PET) scan - Must consent to apolipoprotein E (ApoE) genotyping - If using drugs to treat symptoms related to AD, doses must be stable for at least 8 weeks prior to screening visit 1 - Must have a reliable informant or caregiver Key Exclusion Criteria: - Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the subject's cognitive impairment - Have had a stroke or Transient Ischemic Attack (TIA) or unexplained loss of consciousness in the past 1 year - Clinically significant unstable psychiatric illness in past 6 months - History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening - Indication of impaired renal or liver function - Have human immunodeficiency virus (HIV) infection - Have a significant systematic illness or infection in past 30 days - Relevant brain hemorrhage, bleeding disorder and cerebrovascular abnormalities - Any contraindications to brain magnetic resonance imaging (MRI) or PET scans - Alcohol or substance abuse in past 1 year - Taking blood thinners (except for aspirin at a prophylactic dose or less) NOTE: Other protocol defined Inclusion/Exclusion criteria may apply