The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety of polysomnographic and high-density EEG recordings. Subjects in this protocol will undergo an evaluation which may include: a psychiatric interview; a diagnostic interview; rating scales; a medical history; a physical exam; brain magnetic resonance imaging (MRI); electroencephalography (EEG); electrocardiography (EKG), magnetoencephalography (MEG); blood, saliva and urine laboratory evaluation; and a request for medical records. Subjects may also be asked to complete questionnaires about attitudes towards research and motivation for research participation. The data collected may also be linked with data from other mood and anxiety disorder protocols (e.g., brain imaging, DNA, psychophysiology tests, treatment studies, etc) for the purposes of better understanding the diagnosis, pathophysiology, and treatment response of patients with mood disorders. Parents of minors will be interviewed. Upon conclusion of the screening process, subjects will either be offered participation in a research protocol and will sign the appropriate informed consent, or will be considered not appropriate for participation in research and will be referred back into the community. The current protocol thus serves as an entry point for individuals with mood or anxiety disorders or healthy volunteers to enter NIMH IRB approved ETPB protocols.

Population

Individuals being evaluated for mood and anxiety disorders and healthy volunteers

Brief Title

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

Official Title

The Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

Brief Summary

The purpose of this protocol is to allow for the careful screening of patients and healthy <br /> volunteers for participation in research protocols in the Experimental Therapeutics and <br /> Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the <br /> collection of natural history data. In addition the protocol will allow clinicians to gain <br /> more experience in the use of a variety of polysomnographic and high-density EEG recordings. <br /> Subjects in this protocol will undergo an evaluation which may include: a psychiatric <br /> interview; a diagnostic interview; rating scales; a medical history; a physical exam; brain <br /> magnetic resonance imaging (MRI); electroencephalography (EEG); electrocardiography (EKG), <br /> magnetoencephalography (MEG); blood, saliva and urine laboratory evaluation; and a request <br /> for medical records. Subjects may also be asked to complete questionnaires about attitudes <br /> towards research and motivation for research participation. The data collected may also be <br /> linked with data from other mood and anxiety disorder protocols (e.g., brain imaging, DNA, <br /> psychophysiology tests, treatment studies, etc) for the purposes of better understanding the <br /> diagnosis, pathophysiology, and treatment response of patients with mood disorders. Parents <br /> of minors will be interviewed. Upon conclusion of the screening process, subjects will either <br /> be offered participation in a research protocol and will sign the appropriate informed <br /> consent, or will be considered not appropriate for participation in research and will be <br /> referred back into the community. The current protocol thus serves as an entry point for <br /> individuals with mood or anxiety disorders or healthy volunteers to enter NIMH IRB approved <br /> ETPB protocols.

Detailed Description

The purpose of this protocol is to allow for the careful screening of patients and healthy
volunteers for participation in research protocols on mood and anxiety disorders at the
National Institute of Mental Health (NIMH) and for the collection of natural history data.
Subjects in this protocol will undergo an evaluation which may include: a psychiatric
interview; a diagnostic interview; rating scales; a medical history; a physical exam; brain
magnetic resonance imaging (MRI); computed tomography (CT); electroencephalography (EEG);
electrocardiography (EKG), magnetoencephalography (MEG); blood, saliva and urine laboratory
evaluation; and a request for medical records. The data collected may also be linked with
data from other mood and anxiety disorder protocols (e.g., brain imaging, DNA,
psychophysiology tests, treatment studies, etc) for the purposes of better understanding the
diagnosis, pathophysiology, and treatment response of patients with mood disorders. Parents
of minors will be interviewed. Upon conclusion of the screening process, subjects will either
be offered participation in a research protocol and will sign the appropriate informed
consent, or will be considered not appropriate for participation in research and will be
referred back into the community. The current protocol thus serves as an entry point for
individuals with mood or anxiety disorders or healthy volunteers to enter NIMH IRB approved
protocols.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.