Have you or your loved ones been diagnosed with cushing syndrome?

You may be eligible to participate in a cushing syndrome clinical trial.

Have you or your loved ones been diagnosed with cushing syndrome? You may be eligible to participate in a cushing syndrome clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Cushing Syndrome Clinical Trial in Seoul

NCT01382420 | Interventional

Have you or your loved ones been diagnosed with cushing syndrome?

You may be eligible to participate in a cushing syndrome clinical trial.

Have you or your loved ones been diagnosed with cushing syndrome? You may be eligible to participate in a cushing syndrome clinical trial.

Recruiting

Male & Female

20 - 70

Years old

This study is looking to recruit 234 Participants

Objective: To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma. Methods: 234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

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Details for the study

Brief Title

Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

Official Title

Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

Brief Summary

Objective: To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma. Methods: 234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

Treatments and/or Procedures

Surgery

adrenalectomy

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Primary

Change of lipid profile between two groups

lipid profile with LDL,apo B

4 Year

Secondary

Incidence of obesity between two groups

measurement of body weight, height

4Year

Study Criteria

Inclusion Criteria:

  -  patients with both unilateral adrenal incidentaloma and hypercortisolism

  -  definition of hypercortisolism

       -  overnight dexamethasone suppression test, serum cortisol>1.8ug/dL

       -  24hr urine cortisol > upper reference limit

Exclusion Criteria:

  -  patients who took medication influencing cortisol secretion

  -  patients with definite clinical feature of cushing syndrome

       -  moon face

       -  abdominal striae

       -  skin or proximal muscle atrophy

  -  metabolic syndrome, hyperthyroidism, hyperparathyroidism, chronic renal failure,
     rheumatic disease, hematologic disease

  -  patients who took following medication

       -  insulin

       -  oral hypoglycemic agent

       -  thyroid hormone

       -  anti-hyperlipidemic drug

       -  sex hormone

  -  patients who taking steroid hormone or who took steroid hormone more than 2 weeks
     within 1 year

  -  psychiatric disease