A biomarker cohort study design is proposed to study whether specific airway microbiota alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease. In a cohort of 200 subjects suspected of having pulmonary NTM disease, the investigators will evaluate the airway microbiome using an aliquot of the induced sputum and upper airway samples. Since induced sputum may reflect different regions of the upper/lower airways, the investigators will evaluate the upper and lower airway microbiome in a subgroup (case-control group) of patients using samples obtained through upper airway sampling and bronchoscopy, respectively.

Population

Utilizing cohorts built at NYU over the last several years, this project is uniquely positioned to investigate the microbiome signatures among subjects with NTM disease.

Brief Title

Evaluation Of The Lung Microbiome In NTM Bronchiectasis

Official Title

Evaluation Of The Lung Microbiome In NTM Bronchiectasis

Brief Summary

A biomarker cohort study design is proposed to study whether specific airway microbiota <br /> alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease. In a <br /> cohort of 200 subjects suspected of having pulmonary NTM disease, the investigators will <br /> evaluate the airway microbiome using an aliquot of the induced sputum and upper airway <br /> samples. Since induced sputum may reflect different regions of the upper/lower airways, the <br /> investigators will evaluate the upper and lower airway microbiome in a subgroup (case-control <br /> group) of patients using samples obtained through upper airway sampling and bronchoscopy, <br /> respectively.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.