The primary aims of this study are: 1. To determine the feasibility of deploying mindBEAGLE, a portable, bedside EEG-based system, in the Intensive Care Unit in patients with disorders of consciousness (DOC) or locked-in syndrome (LIS); 2. To determine if mindBEAGLE neurophysiologic markers of cognitive function correlate with bedside behavioral assessments of consciousness; 3. To determine if mindBEAGLE neurophysiologic markers of cognitive function correlate with functional MRI (fMRI) and electroencephalography (EEG) biomarkers of consciousness; 4. To determine if mindBEAGLE can serve as an assistive communication device for people with LIS.

Brief Title

Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome

Official Title

Feasibility Study of the mindBEAGLE Device in Patients With Disorders of Consciousness or Locked-In Syndrome

Brief Summary

The primary aims of this study are: <br /> <br /> 1. To determine the feasibility of deploying mindBEAGLE, a portable, bedside EEG-based <br /> system, in the Intensive Care Unit in patients with disorders of consciousness (DOC) or <br /> locked-in syndrome (LIS); <br /> <br /> 2. To determine if mindBEAGLE neurophysiologic markers of cognitive function correlate with <br /> bedside behavioral assessments of consciousness; <br /> <br /> 3. To determine if mindBEAGLE neurophysiologic markers of cognitive function correlate with <br /> functional MRI (fMRI) and electroencephalography (EEG) biomarkers of consciousness; <br /> <br /> 4. To determine if mindBEAGLE can serve as an assistive communication device for people <br /> with LIS.

Detailed Description

1. To determine the feasibility of deploying mindBEAGLE, a portable, bedside EEG-based
system, in the Neurosciences Intensive Care Unit in patients with DOC or LIS;

2. To determine if mindBEAGLE neurophysiologic markers of cognitive function correlate with
bedside behavioral assessments of consciousness;

3. To determine if mindBEAGLE can serve as an assistive communication device for people
with LIS.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.