Have you or your loved ones been diagnosed with benign frequency syndrome (bfs)?

You may be eligible to participate in a benign frequency syndrome (bfs) clinical trial.

Have you or your loved ones been diagnosed with benign frequency syndrome (bfs)? You may be eligible to participate in a benign frequency syndrome (bfs) clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Benign Frequency Syndrome (BFS) Clinical Trial in Boston MA

NCT00499317 | Observational

Have you or your loved ones been diagnosed with benign frequency syndrome (bfs)?

You may be eligible to participate in a benign frequency syndrome (bfs) clinical trial.

Have you or your loved ones been diagnosed with benign frequency syndrome (bfs)? You may be eligible to participate in a benign frequency syndrome (bfs) clinical trial.

Recruiting

Male

All ages

This study is looking to recruit 500 Participants

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a condition with several causes of which some remain unknown. It is believed that some types of CP may be genetic or passed down (inherited) from one generation to the next. In this study, we are collecting genetic material and medical information to try to determine if genetic factors play a role in CP/CPPS. We will be collecting DNA (from Blood/Saliva sample) and urine from each participant. Bladder tissue from affected individuals will also be collected. Individuals and families with CP/CPPS will be enrolled. Family members of an individual with CP/CPPS are eligible whether or not they also experience CP/CPPS symptoms.

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Details for the study

Population

We are collecting individuals with a diagnoses of CP/CPPS and their family members (with or without symptoms) from North America (United States and Canada). Preference is given to families with multiple affected individuals (males or females with IC/BPS/CPPS).

Brief Title

Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Official Title

Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Brief Summary

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a condition with several causes of which some remain unknown. It is believed that some types of CP may be genetic or passed down (inherited) from one generation to the next. In this study, we are collecting genetic material and medical information to try to determine if genetic factors play a role in CP/CPPS. We will be collecting DNA (from Blood/Saliva sample) and urine from each participant. Bladder tissue from affected individuals will also be collected. Individuals and families with CP/CPPS will be enrolled. Family members of an individual with CP/CPPS are eligible whether or not they also experience CP/CPPS symptoms.

Detailed Description

We would like to determine if chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has
a genetic cause. We will be attempting to further describe the symptoms of CP/CPPS and to
correlate them with changes in your genes. We will use several types of genetic testing;
linkage analysis, whole exome sequencing and candidate gene studies. Each individual
participant will be required to give a DNA sample (via Blood/Saliva), a urine sample and
answer questionnaires. Affected participants will also be asked to provide a bladder sample
from a clinical biopsy. All samples will be stored. Travel to Boston NOT required.

Study Criteria

Inclusion Criteria:

  -  Have symptoms for at least 3 months within the preceding 6 months:

  -  Pain in the pelvic area

  -  Urinary frequency and/or

  -  Urinary urgency and/or

  -  Sexual dysfunction (erectile dysfunction)

  -  Have CP/CPPS, Interstitial Cystitis (IC), Bladder Pain Syndrome BPS, or Bladder
     Fasciculation Syndrome (BFS)

  -  Be willing to provide a blood/saliva, bladder tissue (from previous biopsy) and urine
     sample

  -  Agree to complete several brief questionnaires

  -  Family member of someone with CP/CPPS, BPS, IC or BFS

  -  Live in the USA or Canada

Exclusion Criteria:

  -  Major structural/anatomical urinary tract abnormalities

  -  Underlying inborn or congenital conditions which affect the urinary tract

  -  Surgery/chemotherapy in the pelvic area

  -  Bacterial cause to CP/CPPS or recurrent Urinary tract infections (UTI)

  -  Traumatic cause to CP/CPPS