Esophagogastric Cancer Clinical Trial in Bradford England
NCT00450203
| Phase 2 phase 3
| Interventional
This study is looking to recruit 1103 Participants
RATIONALE: Drugs used in chemotherapy, such as epirubicin, cisplatin, and capecitabine, work
in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Monoclonal antibodies, such as bevacizumab, and small molecule
tyrosine kinase inhibitors, such as lapatinib, can block tumor growth in different ways. Some
block the ability of tumor cells to grow and spread. Others find tumor cells and help kill
them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor
cells by blocking blood flow to the tumor. Lapatinib targets a specific growth receptor,
HER-2. Chemotherapy together with bevacizumab or lapatinib, in HER-2 positive tumours, may
kill more tumor cells.
PURPOSE: This randomized phase II/III trial is studying the side effects and how well giving
combination chemotherapy together with bevacizumab works compared with combination
chemotherapy alone in treating patients with previously untreated stomach cancer,
gastroesophageal junction cancer or lower oesophageal cancer that can be removed by surgery.
The feasibility study is studying the safety of adding lapatinib to chemotherapy in patients
with HER-2 positive previously untreated stomach cancer, gastroesophageal junction cancer or
lower oesophageal cancer that can be removed by surgery. The feasibility study will also
assess the feasibility of timely HER-2 testing and estimate the HER-2 positivity rate in this
patient population.
Details for the study
Brief Title
Chemotherapy With or Without Bevacizumab or Lapatinib to Treat Operable Oesophagogastric Cancer
Official Title
A Randomised Phase II/III Trial of Peri-Operative Chemotherapy With or Without Bevacizumab in Operable Oesophagogastric Adenocarcinoma and A Feasibility Study Evaluating Lapatinib in HER-2 Positive Oesophagogastric Adenocarcinomas and (in Selected Centres) MRI and PET/CT Sub-studies
Brief Summary
RATIONALE: Drugs used in chemotherapy, such as epirubicin, cisplatin, and capecitabine, work<br /> in different ways to stop the growth of tumor cells, either by killing the cells or by<br /> stopping them from dividing. Monoclonal antibodies, such as bevacizumab, and small molecule<br /> tyrosine kinase inhibitors, such as lapatinib, can block tumor growth in different ways. Some<br /> block the ability of tumor cells to grow and spread. Others find tumor cells and help kill<br /> them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor<br /> cells by blocking blood flow to the tumor. Lapatinib targets a specific growth receptor,<br /> HER-2. Chemotherapy together with bevacizumab or lapatinib, in HER-2 positive tumours, may<br /> kill more tumor cells.<br /><br /> PURPOSE: This randomized phase II/III trial is studying the side effects and how well giving<br /> combination chemotherapy together with bevacizumab works compared with combination<br /> chemotherapy alone in treating patients with previously untreated stomach cancer,<br /> gastroesophageal junction cancer or lower oesophageal cancer that can be removed by surgery.<br /> The feasibility study is studying the safety of adding lapatinib to chemotherapy in patients<br /> with HER-2 positive previously untreated stomach cancer, gastroesophageal junction cancer or<br /> lower oesophageal cancer that can be removed by surgery. The feasibility study will also<br /> assess the feasibility of timely HER-2 testing and estimate the HER-2 positivity rate in this<br /> patient population.
Detailed Description
OBJECTIVES:
Primary
- Assess the safety and efficacy of neoadjuvant and adjuvant chemotherapy comprising
epirubicin hydrochloride, cisplatin, and capecitabine with or without bevacizumab in
patients with previously untreated, resectable gastric, gastroesophageal junction or
lower oesophageal cancer.
- Assess the safety of neoadjuvant and adjuvant chemotherapy comprising epirubicin
hydrochloride, cisplatin, and capecitabine with or without lapatinib in patients with
HER-2 positive previously untreated, resectable gastric, gastroesophageal junction or
lower oesophageal cancer.
OUTLINE: This is a multicenter, randomized, open-label, controlled study. Patients are
randomized to 1 of 4 treatment arms.
- Arm I and II: Patients receive epirubicin hydrochloride IV and cisplatin IV over 4 hours
on day 1 and capecitabine orally twice daily on days 1-21. Treatment repeats every 21
days for up to 3 courses in the absence of disease progression or unacceptable toxicity.
Patients undergo surgery 5-6 weeks after completion of chemotherapy. Patients then receive 3
additional courses of chemotherapy beginning 6-10 weeks after surgery.
- Arm II: Patients receive bevacizumab IV over 30-90 minutes, epirubicin hydrochloride IV,
and cisplatin IV over 4 hours on day 1 and capecitabine orally twice daily on days 1-21.
Treatment repeats every 21 days for up to 3 courses in the absence of disease
progression or unacceptable toxicity.
Patients undergo surgery 5-8 weeks after completion of chemotherapy. Patients then receive 3
additional courses of chemotherapy and bevacizumab beginning 6-10 weeks after surgery.
Patients then receive maintenance therapy comprising bevacizumab IV over 30-90 minutes on day
1. Maintenance therapy repeats every 21 days for up to 6 courses in the absence of disease
progression or unacceptable toxicity.
- Arm IV: Patients receive lapatinib orally once daily, epirubicin hydrochloride IV, and
cisplatin IV over 4 hours on day 1 and capecitabine orally twice daily on days 1-21.
Treatment repeats every 21 days for up to 3 courses in the absence of disease
progression or unacceptable toxicity.
Patients undergo surgery 5-8 weeks after completion of chemotherapy. Patients then receive 3
additional courses of chemotherapy and lapatinib beginning 6-10 weeks after surgery. Patients
then receive maintenance therapy comprising lapatinib orally once daily on days 1-21.
Maintenance therapy repeats every 21 days for up to 6 courses in the absence of disease
progression or unacceptable toxicity.
Quality of life is assessed at baseline, during treatment, and during the follow-up period.
After completion of study treatment, patients are followed at 9, 18, and 27 weeks after the
start of course 4, 1 year post surgery, every 6 months for 2 years, and then annually
thereafter.
PROJECTED ACCRUAL: A total of 1063 patients were recruited to the bevacizumab comparison of
the study (now closed to recruitment) and 40 patients with HER-2 positive tumours will be
recruited into the ST03 feasibility study.
Treatments and/or Procedures
Bevacizumab
7.5mg/kg IV Day 1 of each 21 cycle of chemotherapy (6 cycles) plus day 1 of each maintenance dose every 21 days for 6 doses.
Lapatinib
1250mg/day Day 1-21 of each cycle of chemotherapy (6 cycles) plus day 1-21 of each maintenance course every 21 days for 6 doses.
Epirubicin
50mg/m2 IV day one of each 21 day cycle of chemotherapy (6 cycles in total)
Cisplatin
60mg/m2 IV day one of each 21 day cycle of chemotherapy (6 cycles in total)
Capecitabine
dose banded as based on patient BSA. Oral dose given twice a day during each 21 day cycle of chemotherapy (6 cycles in total)
Neoadjuvant therapy
3 cycles of pre-operative ECX chemotherapy.
Conventional surgery
Surgery undertaken after 3 cycles of pre-operative chemotherapy. Followed by 3 cycles of chemotherapy.
Adjuvant therapy
3 cycles of ECX chemotherapy post operatively
Study Criteria
This is a combined eligibility criteria for both bevacizumab comparison and the lapatinib
feasibility study. Please note the bevacizumab comparison closed to recruitment on 28th
March 2014.
DISEASE CHARACTERISTICS:
- Histologically confirmed gastric or type I, II or III gastroesophageal junction
adenocarcinoma or lower oesophageal
Gastric and Type III junctional tumours should be Stage Ib (T1 N1, T2a/b N0), II, III or
stage IV (T4 N1 or N2) with no evidence of distant metastases (M0)
Lower oesophageal and Type I and II junctional tumours should be Stage II to Stage IVa (T1
N1, T2 N1, T3 N0-1, but not T2N0). T4 (N0 or N1) tumours are also eligible providing that
they involve only the crura OR invade only the mediastinal pleura. Patients with nodal
disease affecting the origin of the left gastric and splenic artery or coeliac axis (staged
as M1a) are also eligible.
- Resectable disease
- Previously untreated disease
PATIENT CHARACTERISTICS:
- WHO performance status 0 or 1
- Absolute neutrophil count ≥ 1,500/mm^3
- Platelet count ≥ 100,000/mm^3
- Hemoglobin ≥ 9 g/dL (can be post transfusion)
- WBC ≥ 3,000/mm^3
- Glomerular filtration rate ≥ 60 mL/min
- Proteinuria ≤ 1 g by 24-hour urine collection
- Bilirubin ≤ 1.5 times upper limit of normal (ULN)
- ALT and AST ≤ 2.5 times ULN
- Alkaline phosphatase ≤ 3 times ULN (in the absence of liver metastases)
- INR ≤ 1.5
- PTT ≤ 1.5 times ULN
- FEV_1 ≥ 1.5 L
- Cardiac ejection fraction ≥ 50% by MUGA scan or echocardiogram
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- Must be fit enough to receive protocol treatment
- No other malignancies within the past 5 years except for curatively treated basal cell
carcinoma of the skin and/or in situ carcinoma of the cervix
- No prior or concurrent significant medical conditions, including any of the following:
- Cerebrovascular disease (including transient ischemic attack and stroke) within
the past year
- Cardiovascular disease, including the following:
- Myocardial infarction within the past year
- Uncontrolled hypertension while receiving chronic medication
- Unstable angina
- New York Heart Association class II-IV congestive heart failure
- Serious cardiac arrhythmia requiring medication
- Major trauma within the past 28 days
- Serious nonhealing wound, ulcer, or bone fracture
- Evidence of bleeding diathesis or coagulopathy
- Recent history of any active gastrointestinal inflammatory condition (e.g.,
peptic ulcer disease, diverticulitis, or inflammatory bowel disease)
- If patients have a known diagnosis of any of the above, evidence of disease
control is required by negative endoscopy within the past 28 days
- No severe tinnitus
- No lack of physical integrity of the upper gastrointestinal tract, malabsorption
syndrome, or inability to take oral medication
- No known peripheral neuropathy ≥ 1 (absence of deep tendon reflexes as the sole
neurological abnormality does not render the patient ineligible)
- No known dihydropyrimidine dehydrogenase deficiency
- No history of interstitial lung disease or radiological evidence of lung fibrosis
- No known allergy to any of the following:
- Chinese hamster ovary cell proteins
- Other recombinant human or humanized antibodies
- Any excipients of bevacizumab formulation or platinum compounds
- Any other components of the study drugs
Due to an increase in perforations associated with self-expandable metal stents in patients
with colorectal cancer receiving bevacizumab, patients with an oesophageal or gastric stent
(metal or biodegradable) in situ are ineligible for the study.
PRIOR CONCURRENT THERAPY:
- No prior anthracycline
- More than 28 days since prior major surgery or open biopsy
- More than 10 days since prior thrombolytic therapy
- No concurrent thrombolytic therapy
- No concurrent dipyridamole
- No concurrent capecitabine or sorivudine (or sorivudine analogues [e.g., brivudine])
- No chronic, daily high-dose acetylsalicylic acid (> 325 mg/day) or nonsteroidal
anti-inflammatory drugs
- No chronic corticosteroids (≥ 10 mg/day methylprednisolone equivalent)
- Inhaled steroids allowed
- No other concurrent cytotoxic agents
- No other concurrent investigational drugs
- No concurrent radiotherapy
- Low molecular weight heparin allowed
- More than 7 days since prior CYP3A4 inhibitor therapy
- More than 14 days since prior CYP3A4 inducer therapy
- More than 6 months since prior amiodarone therapy
- More than 14 days since prior St John's Wort, modafinil, ginkgo biloba, kava, grape
seed, valerian, ginseng, echinacea and evening primrose oil