The purpose of the study is to determine the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and associated OSA (obstructive sleep apnea).

Brief Title

Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)

Official Title

Treatment Resistant Depression and Obstructive Sleep Apnea: Effect of Treatment With CPAP on Mood, Anxiety and Quality of Life

Brief Summary

The purpose of the study is to determine the effect on mood and anxiety symptoms of adding<br /> CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and<br /> associated OSA (obstructive sleep apnea).

Detailed Description

Primary objective:

What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment
of patients with TRD and associated OSA?

Secondary objectives:

1. How common is co-morbid OSA in patients with treatment resistant unipolar depression
referred to a tertiary Mood Disorders Clinic?

2. Is there a difference in daytime functioning (severity of depressive and anxiety
symptoms, cognitive function, daytime sleepiness) and sleep quality between patients
with TRD diagnosed with OSA compared with patients with TRD who have no OSA?

3. What is the association between sleep fragmentation and hypoxemia and the severity of
depression in patients with TRD?

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.