RATIONALE: Understanding the relationship between breast density, levels of hormones in the blood, and levels of anticancer drugs in the blood may help improve the ability to plan effective treatment for women with invasive breast cancer. PURPOSE: This clinical trial is studying the relationship between breast density and blood levels of hormones and anticancer drugs in women with invasive breast cancer who are receiving exemestane or anastrozole.

Population

Patients with diagnosed with breast cancer.

Brief Title

Breast Density, Hormone Levels, and Anticancer Drug Levels in Women With Invasive Breast Cancer Who Are Receiving Exemestane or Anastrozole

Official Title

The Association of Breast Density Changes, Plasma Hormone Changes, and Breast Cancer Recurrence: A Companion Study to NCIC CTG MA.27

Brief Summary

RATIONALE: Understanding the relationship between breast density, levels of hormones in the<br /> blood, and levels of anticancer drugs in the blood may help improve the ability to plan<br /> effective treatment for women with invasive breast cancer.<br /><br /> PURPOSE: This clinical trial is studying the relationship between breast density and blood<br /> levels of hormones and anticancer drugs in women with invasive breast cancer who are<br /> receiving exemestane or anastrozole.

Detailed Description

OBJECTIVES:

Primary

- Assess the change in percent breast density and dense area in response to aromatase
inhibitor therapy from pretreatment to 1 year, 1 year to 2 years, and pretreatment to 2
years in women with invasive breast cancer.

- Determine the changes in percent breast density and dense area in response to aromatase
inhibitor therapy from pretreatment to 1 year and correlate the changes with changes in
plasma hormones (e.g., estrone, estrone-sulfate, estradiol, and sex hormone binding
globulin) and drug levels (anastrozole or exemestane) over the same period in women with
invasive breast cancer.

- Determine the change over time in percent breast density and dense area (from
pretreatment to the time period prior to local recurrence) in the contralateral breast
in correlation to local recurrence of breast cancer.

Secondary

- Determine the change over time in percent breast density and dense area in the
contralateral breast in correlation to the development of contralateral breast cancer.

- Determine whether women with high pretreatment percent density (upper tertile)
experience greater decreases in percent breast density at 1 and 2 years of aromatase
inhibitor therapy than women with low pretreatment percent density (lower tertile).

- Determine whether women with high pretreatment dense area (upper tertile) experience
greater decreases in dense area at 1 and 2 years of aromatase inhibitor therapy than
women with low pretreatment dense area (lower tertile).

- Correlate haplotype tagged single nucleotide polymorphisms in genes in the aromatase
pathway (identified thorough the Mayo Clinic and Indiana University Pharmacogenomics
Research Network Projects) with changes in percent and area breast density, plasma
hormone levels, and 1-year drug levels.

OUTLINE: This is a multicenter, companion study.

Patients complete a 10-minute questionnaire about factors that might affect changes in breast
density at baseline and another questionnaire at 1 year and 2 years post registration. Blood
samples are collected at baseline (before initiation of treatment ) and at 1 year post
registration for hormone and drug level analysis. Mammograms taken prior to registration
(within 12 months prior to enrollment) and at approximately 1 and 2 years post-registration
to this study are retrieved and digitized for determination of percent breast density and
dense area.

PROJECTED ACCRUAL: A total of 550 patients will be accrued for this study.