Have you or your loved ones been diagnosed with anemia?

You may be eligible to participate in a anemia clinical trial.

Have you or your loved ones been diagnosed with anemia? You may be eligible to participate in a anemia clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Anemia Clinical Trial
NCT00303784 | Phase 3 | Interventional

Have you or your loved ones been diagnosed with anemia?

You may be eligible to participate in a anemia clinical trial.

Have you or your loved ones been diagnosed with anemia? You may be eligible to participate in a anemia clinical trial.

Recruiting

Male

Up to 120

Years old

This study is looking to recruit 2200 Participants

RATIONALE: The increasingly prolonged and extended use of androgen deprivation therapy (ADT) in the treatment of prostate cancer, usually achieved through the administration of LHRH agonists, has raised concerns about long-term toxicities, in particular osteoporosis and adverse metabolic changes which may be associated with type II diabetes and increased cardiovascular risk. An alternative approach is to investigate other methods of ADT. Oral oestrogen has been shown to be as effective as LHRH and surgical orchidectomy in achieving castrate levels of testosterone and has equivalent or improved prostate cancer outcomes but is not used routinely as first-line therapy because of the risk of cardiovascular system (CVS) complications. The CVS complications have been attributed to first-pass hepatic metabolism. Administering oestrogen parenterally avoids the entero-hepatic circulation and so is expected to mitigate the risk of CVS toxicity whilst still effectively suppressing testosterone to castrate levels. This hypothesis has been supported by results from the early stages of this trial which have provided sufficient indication of the safety and efficacy of the patches to warrant further investigation of the treatment in this setting, as recommended by the IDMC.. PURPOSE: This randomized phase III trial is studying how well the estrogen skin patch works compared with luteinizing hormone-releasing hormone agonist injections in treating patients with locally advanced or metastatic prostate cancer.