Have you or your loved ones been diagnosed with acute rhinosinusitis?

You may be eligible to participate in a acute rhinosinusitis clinical trial.

Have you or your loved ones been diagnosed with acute rhinosinusitis? You may be eligible to participate in a acute rhinosinusitis clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Acute Rhinosinusitis Clinical Trial in Richmond VA

NCT01553110 | Observational

Have you or your loved ones been diagnosed with acute rhinosinusitis?

You may be eligible to participate in a acute rhinosinusitis clinical trial.

Have you or your loved ones been diagnosed with acute rhinosinusitis? You may be eligible to participate in a acute rhinosinusitis clinical trial.

Completed

Male & Female

12 - 100

Years old

This study has recruited 41 Participants

This is a study to learn more about the common cold from studying the nasal secretions produced during a cold or episode of allergic rhinitis.

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Details for the study

Population

Primary Care Clinics and Community

Brief Title

An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms

Official Title

An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms in Acute Rhinosinusitis.

Brief Summary

This is a study to learn more about the common cold from studying the nasal secretions<br /> produced during a cold or episode of allergic rhinitis.

Detailed Description

This study involves collecting and analyzing nasal mucus to see if there are changes in mucus
properties during the course of a cold or episode of allergic rhinitis. Outcome measures
include SNOT20 questionnaire, nasal secretion collection, acoustic rhinometry on the fifth
and fourteenth day of symptoms. The investigators will also collect SNOT20 questionnaires on
the tenth and twenty-eighth day.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Primary

Nasal Secretion Collection

To measure the biophysical properties of nasal secretions for improved mucus clearance.

10 minutes

Secondary

Subjective nasal scoring

The Sinus and Nasal Quality of Life Survey (SN-20) questionnaire assess the impact of infection on nasal symptoms, emotion, and activity on a scale of worsening symptoms scored 1 through 7 to provide a quantifiable score capable of comparing both disease severity and the impact of interventions on subjective complaints.

10 Minutes

Secondary

Nasal Volume

Acoustic rhinometry is used to measure cross-sectional volume of the nasal cavity allowing the calculation of nasal volume.

15 Minutes

Study Criteria

Inclusion Criteria:

  -  Male and female subjects 12 years of age and older with acute nasal discharge fewer
     than 7 days or a history suggesting nasal allergic symptoms for at least 1 year.
     Internet access required during the course of the study. Patients must be symptomatic
     at screening.

Exclusion Criteria:

  -  Symptoms suggesting bacterial rhinosinusitis such as fever ≥ 101ºF/38.3ºC, facial
     swelling, and serve tooth pain. History of CRS or sinus/nasal surgery for this
     condition within 6 months before screening. History of respiratory signs and symptoms
     due to allergic rhinitis. Therapy with bronchodilators, nasal steroids, oral
     corticosteroids in the past 30 days. Therapy with antihistamines, nasal (Neti)
     washings, or decongestants in the past 24 hours. Use of any OTC cold or allergy
     medication 24 hours before study visits requires a 24 hour washout phase