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Asthma in Children Clinical Trial in Paris
Have you or your loved ones been diagnosed with asthma in children?
You may be eligible to participate in a asthma in children clinical trial.
Have you or your loved ones been diagnosed with asthma in children? You may be eligible to participate in a asthma in children clinical trial.
Completed
Male & Female
5 - 6
Years old
Early lung function deficits represent a significant risk factor for the evolution toward chronic obstructive pulmonary disease later in life. Prematurity and in utero tobacco smoke exposure are already known to predispose children to develop a non-reversible obstructive ventilatory defect in adulthood. The role of vitamin D status during pregnancy is less certain. In humans, low vitamin D concentrations during pregnancy are associated to an increased risk of asthma in children. In murine models, low vitamin D concentrations during pregnancy are associated to structural abnormalities of the airways in mouse pups. Investigators hypothesized that vitamin D play a role in early airways development, from the first trimester of pregnancy. To bring arguments to this hypothesis, the investigators will study the association of airway resistance in children aged 5 to 6 years old with the concentration of vitamin D during the first trimester of pregnancy in their mothers.