To measure the cerebral hemodynamic effect of L-kynurenine.

Brief Title

The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers

Official Title

The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers

Brief Summary

To measure the cerebral hemodynamic effect of L-kynurenine.

Detailed Description

Aim: To investigate the physiological effect of L-Kynurenine after intravenous administration
to healthy volunteers.

Hypothesis: L-kynurenine induces vasodilation in the cerebral vessels and trigger headache in
healthy individuals.

Methods: 6 healthy volunteers will receive intravenous infusion of L-kynurenine using the
following doses 50 microgram/kg, 100 microgram/kg, 150 microgram/kg, 300 microgram/kg, 500
microgram/kg, 1 mg/kg and 5 mg/kg over 20 min on 7 different days with at least 1 day in
between. Before and after infusion (at 20, 40, 60, 80 and 100 min) we will record vital
signs, circumferences of middle cerebral artery, superficial temporalis artery and headache
intensity and characteristics.

The subjects will then have a questionnaire about headache for the following 24 hours.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.