The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.

Brief Title

Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline

Official Title

Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline

Brief Summary

The overall objective of this study is to examine the effect of polyamine supplementation on <br /> cognitive performance and further characterization of individuals with subjective cognitive <br /> decline.

Detailed Description

Memory abilities are known to decline during aging, a process that is accelerated in
pathological conditions like mild cognitive impairment (MCI) and Alzheimer's disease (AD),
all of which are a growing public-health concern with devastating social and economical
effects. Polyamines supplementation and corresponding up-regulation of autophagy (i.e.,
cellular protein degradation pathways) may be a key target of intervention against
age-related memory decline. The study will investigate whether a polyamine-enriched dietary
supplementation (through capsule intake) could provide positive effects on cognitive function
and biomarkers of elderly individuals (60-90 years old) with subjective cognitive decline
(SCD).

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Inclusion Criteria:

  -  Cognitive healthy individuals with subjective memory decline and self-reported
     concerns

  -  60-90 years old

  -  No manifest dementia (DSM-IV criteria)

  -  No limitations in activities of daily living

  -  Capacity for consent

Exclusion Criteria:

  -  Gluten, histamine or wheat seedling intolerance

  -  Severe neurological, internal or psychological diseases

  -  Advanced heart or respiratory diseases, severe arteriosclerosis, untreated thyroid
     disease or diabetes

  -  Malignant tumors, current or past history

  -  Brain tumors, stroke

  -  Disorders that impair attention

  -  Dementia

  -  Coagulation disorder, Marcumar

  -  Drug abuse or alcohol dependency

  -  Current polyamine substitution