Are you healthy and looking to help advance medical science?

You may be eligible to participate in a colon cancer clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a colon cancer clinical study, and could be compensated for your time.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Colon Cancer Clinical Trial in Portland OR

NCT01344330 | Observational

Are you healthy and looking to help advance medical science?

You may be eligible to participate in a colon cancer clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a colon cancer clinical study, and could be compensated for your time.

Completed

Male & Female

50 - 75

Years old

This study has recruited 108 Participants

This research study will assess cruciferous vegetable intake in patients presenting for screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of cruciferous vegetable intake.

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Details for the study

Population

Patients scheduled for screening colonoscopy

Brief Title

Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Official Title

Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Brief Summary

This research study will assess cruciferous vegetable intake in patients presenting for <br /> screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) <br /> expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The <br /> investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of <br /> cruciferous vegetable intake.

Study Criteria

Inclusion criteria:

  -  scheduled for screening colonoscopy

  -  off NSAID or aspirin therapy in accordance with OHSU endoscopy clinic guidelines

  -  INR 0.90-1.20

  -  hemoglobin ≥ 13.5 (men) or 12.0 (women)

  -  platelets ≥100,000/μL

  -  Chem screen results within normal limits

  -  negative (serum or urine) pregnancy test done ≤7 days prior to colonoscopy for women
     of childbearing potential only

  -  ASA performance status <2

Exclusion criteria:

  -  history of colon cancer or adenomatous polyps

  -  current smoker

  -  medical history of chronic obstructive pulmonary disease

  -  current oral steroid therapy

  -  current therapy with valproate or other pharmacological drugs associated with HDAC
     inhibition

  -  use of oral antibiotics within 3 months prior to entry into study

  -  significant active medical illness which in the opinion of the investigator would
     preclude collection/interpretation of colon tissue

  -  diagnosis of hemophilia, van Willebrand's disease or other bleeding disorder

  -  use of warfarin or other blood thinning agents

  -  inflammatory bowel disease.