This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression.

Brief Title

Family Cognitive Behavioral Therapy for Preventing Depression in Children

Official Title

Family Cognitive Behavioral Prevention of Depression in Children of Parents With a History of Major Depressive Disorder

Brief Summary

This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus <br /> educational treatment in preventing depression in the children of parents with a history of <br /> depression.

Detailed Description

Depression is a serious condition that can affect a person's work, relationships, and quality
of life. Studies have shown that children of depressed parents are at a higher risk for
developing depression than those whose parents have not experienced depression. Safe and
effective treatments that can help prevent children of depressed parents from becoming
depressed are needed. This study will compare CBT to depression education to determine which
is more effective in preventing depression in the children of depressed parents.

Families will be randomly assigned to receive weekly sessions of either CBT or depression
education for 12 weeks. Parents in the CBT group will be taught skills to more effectively
raise their children and to better manage their depressive symptoms; their children will be
taught skills to cope with the stress of their parents' depression. Families in the education
group will be informed about the ways that depression can affect individuals with depression
and their families.

Study visits will occur at study entry and at Week 12. Several follow-up visits will occur
for up to 2 years after the interventional part of the study. At each visit, a clinician will
make direct observations of the depressed parent's interaction with his or her children. In
addition, families will be interviewed and will complete questionnaires about the parent's
depressive symptoms and family interaction.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Inclusion Criteria for Participating Families:

  -  Families with at least one parent with a history of depression during the life of his
     or her child

  -  Families with at least one child between the age of 10 and 15

  -  Parent or guardian willing to provide informed consent for participating children

Exclusion Criteria for All Participants:

  -  Parent with bipolar disorder or schizophrenia

  -  Child with conduct disorder or pervasive developmental disorder