CRiALS is an umbrella protocol through which people are recruited to participate in a range of research studies being conducted by the ALS Research Collaboration (ARC).

Population

The CRiALS research program aims to recruit three types of participants: - Individuals affected with ALS or a related neurodegenerative disease - Unaffected individuals from pedigrees in which the genetic cause of ALS is known - Healthy controls

Brief Title

Clinical Research in ALS Study

Official Title

Clinical Research in Amyotrophic Lateral Sclerosis

Brief Summary

CRiALS is an umbrella protocol through which people are recruited to participate in a range <br /> of research studies being conducted by the ALS Research Collaboration (ARC).

Detailed Description

Research goals include elucidation of the complex relationship between ALS and related
neurodegenerative disorders, development of both wet and dry biomarkers of disease, and
delineation of the full course of the natural history of disease from the early
pre-symptomatic stages through established and even late-stage disease. These goals are
accomplished through the recruitment and evaluation of patients with ALS and related
diseases, family members (including people at genetic risk for ALS, but who are not yet
affected), and healthy controls.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.