Have you or your loved ones been diagnosed with pancreatic cancer?

You may be eligible to participate in a pancreatic cancer clinical trial.

Have you or your loved ones been diagnosed with pancreatic cancer? You may be eligible to participate in a pancreatic cancer clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Recruiting for this study? Get access to patient recruitment tools.
Pancreatic Cancer Clinical Trial
NCT04969835 | Phase 1 | Interventional

Have you or your loved ones been diagnosed with pancreatic cancer?

You may be eligible to participate in a pancreatic cancer clinical trial.

Have you or your loved ones been diagnosed with pancreatic cancer? You may be eligible to participate in a pancreatic cancer clinical trial.

Recruiting

Male & Female

18 Years +

This study is looking to recruit 80 Participants

This open-label, First-into-Human (FIH) study will evaluate the safety, tolerability, pharmacokinetics (PK) and early efficacy of AVA6000, a FAP-activated pro-drug of doxorubicin, in patients with locally advanced and/or metastatic solid tumours. In Phase Ia, using a 3+3 design, escalating doses of AVA6000 will be administered to patients with a range of solid tumour types to determine the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D). In Phase 1b, the selected RP2D dose will be assessed in one to three tumour types.

Available locations
The Royal Marsden NHS Foundation Trust

The Royal Marsden NHS Foundation Trust

Recruiting London, GBR SM2 5PT

The Christie NHS Foundation Trust

The Christie NHS Foundation Trust

Recruiting Manchester, GBR M20 4BX

The Beatson West of Scotland Cancer Centre NHS Greater Glasgow Clyde

The Beatson West of Scotland Cancer Centre NHS Greater Glasgow Clyde

Not yet recruiting Glasgow, GBR G12 0YN

The Freeman Hospital Newcastle upon Tyne NHS Foundation Trust

The Freeman Hospital Newcastle upon Tyne NHS Foundation Trust

Not yet recruiting Newcastle upon Tyne, GBR NE7 7DN

Weston Park Cancer Centre Sheffield Teaching Hospitals NHS Foundation Trust

Weston Park Cancer Centre Sheffield Teaching Hospitals NHS Foundation Trust

Not yet recruiting Sheffield, GBR S10 2SJ

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