This clinical research study will identify biologic and lifestyle factors which increase a person's risk of developing specific cancer. Researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.

Population

Any patient who have been diagnosed with bladder cancer or who is healthy is eligible to participate without regard to age, sex, or ethnicity.

Brief Title

Genetic Susceptibility to Bladder Cancer

Official Title

Genetic Susceptibility to Bladder Cancer: A Molecular Epidemiology Approach

Brief Summary

This clinical research study will identify biologic and lifestyle factors which increase a <br /> person's risk of developing specific cancer. Researchers propose to conduct a case-control <br /> study examining interindividual differences in susceptibility to tobacco carcinogenesis as <br /> predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis <br /> and this will include studies of the genetic modulation of carcinogen activation and <br /> detoxification and of chromosome sensitivity to tobacco mutagens.

Detailed Description

Researchers propose to conduct a case-control study examining interindividual differences in
susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will
measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic
modulation of carcinogen activation and detoxification and of chromosome sensitivity to
tobacco mutagens.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.