- Purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the pre-symptomatic stage of Parkinson's disease (PD). - Procedures - All subjects (RBD diagnosis and controls) will have 1) a medical and neuro history and physical including videotape of movements, 2) neuropsychological testing, 3) a sleep study, 4) olfactory testing, 5) blood draw for serum testing , 6) functional MRI. All of these procedures are often performed clinically in the diagnosis of PD. Enrollment of subjects with PD is complete. Any testing performed prior to enrollment as part of the clinical evaluation may be used in place of repeating the procedure for the study. Subjects will be followed for 5 years. It is hypothesized that a 5 year follow up may capture a significant number of pre-Parkinson's subjects who will be diagnosed. Subjects may be offered a repeat enrollment after 5 years.

Population

Patients with polysomnographically-documented RBD, non-neurodegenerative diagnosis Age and gender matched non-RBD diagnosis, non-neurodegenerative diagnosis idiopathic PD diagnosis atypical PD diagnosis

Brief Title

RBD Longitudinal as Prognostic for PD

Official Title

A Natural History Analysis of Rapid Eye Movement Sleep Behavior Disorder as Prognostic for Parkinson's Disease

Brief Summary

- Purpose - to validate a combination of biological and clinical markers in the <br /> rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the <br /> pre-symptomatic stage of Parkinson's disease (PD). <br /> <br /> - Procedures - All subjects (RBD diagnosis and controls) will have 1) a medical and neuro <br /> history and physical including videotape of movements, 2) neuropsychological testing, 3) <br /> a sleep study, 4) olfactory testing, 5) blood draw for serum testing , 6) functional <br /> MRI. All of these procedures are often performed clinically in the diagnosis of PD. <br /> Enrollment of subjects with PD is complete. Any testing performed prior to enrollment as <br /> part of the clinical evaluation may be used in place of repeating the procedure for the <br /> study. Subjects will be followed for 5 years. It is hypothesized that a 5 year follow up <br /> may capture a significant number of pre-Parkinson's subjects who will be diagnosed. <br /> Subjects may be offered a repeat enrollment after 5 years.

Detailed Description

Enrollment of PD and PS cohorts is complete. Currently enrolling only confirmed RBD and
Controls.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.