Have you or your loved ones been diagnosed with bronchiectasis adult?

You may be eligible to participate in a bronchiectasis adult clinical trial.

Have you or your loved ones been diagnosed with bronchiectasis adult? You may be eligible to participate in a bronchiectasis adult clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Bronchiectasis Adult Clinical Trial in Taipei

NCT03467035 | Observational patient registry

Have you or your loved ones been diagnosed with bronchiectasis adult?

You may be eligible to participate in a bronchiectasis adult clinical trial.

Have you or your loved ones been diagnosed with bronchiectasis adult? You may be eligible to participate in a bronchiectasis adult clinical trial.

Recruiting

Male & Female

20 Years +

This study is looking to recruit 80 Participants

The objectives of this research grant are to determine the association of hypoxia with the severity of osteoporosis in the patients with bronchiectasis and whether the mechanism of inflammation is triggered by inflammasones, which makes it more prone to osteoporosis in patients with bronchiectasis.

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Details for the study

Population

80 adult patients with proven bronchiectasis, diagnosed by high-resolution computed tomography (HRCT), will be recruited from our outpatient clinic of Chang Gung Memorial Hospital with written informed consent. The inclusion and exclusion criteria are described above.

Brief Title

Role of NLRP3 Inflammasone and Hypoxia in the Severity of Osteoporosis in Patients With Bronchiectasis

Official Title

Role of NLRP3 Inflammasone and Hypoxia in the Severity of Osteoporosis in Patients With Bronchiectasis

Brief Summary

The objectives of this research grant are to determine the association of hypoxia with the<br /> severity of osteoporosis in the patients with bronchiectasis and whether the mechanism of<br /> inflammation is triggered by inflammasones, which makes it more prone to osteoporosis in<br /> patients with bronchiectasis.

Detailed Description

80 patients with proven bronchiectasis, diagnosed by high-resolution computed tomography
(HRCT), will be recruited from our outpatient clinic of Chang Gung Memorial Hospital with
written informed consent. Inclusion criteria are: daily sputum > 10 ml; absence of asthma or
other unstable systemic diseases; and "steady-state" bronchiectasis (< 10% alteration of 24 h
sputum volume, FEV1, and FVC, and in the absence of deterioration in respiratory symptoms at
baseline visits). Exclusion criteria include: unreliable clinic attendance; regular user of
inhaled or oral corticosteroids; history of lung resection and known asthma defined according
to American Thoracic Society guidelines.

The lung function and desaturation will be assessed by six-minute walking tests and the
severity of disease will be evaluated by HRCT scores. Peripheral blood sample (40ml/person)
is performed to analyze the bone turnover markers and the level of Hif in PBMC.

Treatments and/or Procedures

Inflammasone

Serum level of cytokine and RT-PCR for PBMC

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Primary

six minute walk test

six minute walk test distance

6 months

Study Criteria

Inclusion Criteria:

  1. willing to sign a written consent form

  2. Male and female subjects with bronchiectasis diagnosed by high-resolution computed
     tomography

  3. willing to accept 6-minute exercise pulmonary function test and blood draw

  4. Men and women over the age of 20

  5. Has undergone chest computed tomography and bone density examination in the recent
     five years

Exclusion Criteria:

  1. pregnant women or lactating women

  2. asthma, lung resection history before the screening period

  3. active Tuberculosis infection

  4. Have received oral steroid treatment within 30 days

  5. current acute attack or clinical symptoms instability of bronchiectasis