Are you or your loved ones suffering from diffuse intrinsic pontine glioma?

You may be eligible to participate in a diffuse intrinsic pontine glioma clinical trial.

Are you or your loved ones suffering from diffuse intrinsic pontine glioma? You may be eligible to participate in a diffuse intrinsic pontine glioma clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

H3 K27M-mutant High-Grade Glioma incl. DIPG
NCT03416530 | Phase 1 | Interventional
Oncoceutics Inc
Sponsored by
Oncoceutics Inc

Are you or your loved ones suffering from diffuse intrinsic pontine glioma?

You may be eligible to participate in a diffuse intrinsic pontine glioma clinical trial.

Are you or your loved ones suffering from diffuse intrinsic pontine glioma? You may be eligible to participate in a diffuse intrinsic pontine glioma clinical trial.

Recruiting

Male & Female

2 - 18

years old

This study is looking to recruit 69 Participants

This is a multicenter, open-label, four arm, dose escalation, phase I study of oral ONC201 in pediatric patients with newly diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) and recurrent/refractory H3 K27M gliomas. Arm A will define the RP2D for single agent ONC201 in pediatric patients with glioma who are positive for the H3 K27M mutation (positive testing in CLIA laboratory) and have completed at least one line of prior therapy. This will allow for recurrent patients and also patients who have not yet recurred, but have completed radiation and will inevitably recur based on prior clinical experience and the literature. Arm B will define the RP2D for ONC201 in combination with radiation in pediatric patients with newly diagnosed DIPG. Arm C will determine intratumoral drug concentrations and biomarker expression in pediatric patients with midline gliomas. Arm D will determine H3 K27M DNA levels and drug concentrations in the CSF of pediatric H3 K27M-mutant glioma patients.

Where you'll go

Selected location

New York University

New York University Change

New York, NY, USA 10016

Sharon Gardner, MD 646-929-7870

Map | Learn more
Available locations
University of Michigan Cancer Center

University of Michigan Cancer Center

Recruiting 1500 East Medical Center Drive, Ann Arbor, MI, USA 48109

M D Anderson Cancer Center

M D Anderson Cancer Center

Recruiting 1515 Holcombe Boulevard, Houston, TX, USA 77030

Miami Cancer Institute

Miami Cancer Institute

Recruiting 8900 North Kendall Drive, Miami, FL, USA 33176

Interested in participating?
Selected location

New York University

New York, NY, USA 10016

Sharon Gardner, MD 646-929-7870


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