Have you or your loved ones been diagnosed with angina pectoris?

You may be eligible to participate in a angina pectoris clinical trial.

Have you or your loved ones been diagnosed with angina pectoris? You may be eligible to participate in a angina pectoris clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Angina Pectoris Clinical Trial in New York NY

NCT02347215 | Interventional

Have you or your loved ones been diagnosed with angina pectoris?

You may be eligible to participate in a angina pectoris clinical trial.

Have you or your loved ones been diagnosed with angina pectoris? You may be eligible to participate in a angina pectoris clinical trial.

Completed

Male & Female

21 - 100

Years old

This study has recruited 212 Participants

Serial assessment of angina status and ischemia on stress echo over one year among patients with moderate ischemia on stress imaging and non-obstructive CAD on coronary CT angiography.

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Details for the study

Brief Title

Changes in Ischemia and Angina Over 1 Year Among ISCHEMIA Trial Screen Failures With no Obstructive CAD on Coronary CT Angiography

Official Title

Changes in Ischemia and Angina Over One Year Among ISCHEMIA Trial Screen Failures

Brief Summary

Serial assessment of angina status and ischemia on stress echo over one year among patients<br /> with moderate ischemia on stress imaging and non-obstructive CAD on coronary CT angiography.

Detailed Description

Some people with chest pain are found to have open arteries on angiograms instead of blocked
arteries and many, but not all, of these people have abnormal stress tests or other tests
showing there is not enough blood flow to the heart. Prior research has not made clear
whether chest pain in such patients is due to heart disease or something else, in part
because no one has found out whether chest pain and stress test results change in the same
direction over time. This study will use two measurements of chest pain and two stress tests,
one year apart, to find out if chest pain and abnormal stress tests are both caused by the
same problem: not enough blood flow to the heart.The association between angina, ischemia and
atherosclerosis severity at baseline will be examined, as will medication effects.

Treatments and/or Procedures

Stress imaging

Quality of life assessment

Seattle Angina Questionnaire and other questionnaires.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Secondary

Coronary atherosclerosis severity (comparison with SAQ score and with ischemia severity)

comparison with SAQ score and with ischemia severity

baseline

Secondary

Ischemia severity (comparison with SAQ score and with ischemia severity)

comparison with SAQ score and with atherosclerosis severity

baseline

Secondary

Medical therapy used for angina (comparison with SAQ score and ischemia severity)

comparison with SAQ score and ischemia severity

one year

Secondary

Major adverse cardiac events

death, MI, stroke, cardiovascular hospitalizations/ER visits

one year

Study Criteria

Inclusion Criteria:

  -  Enrolled but not randomized in ISCHEMIA trial

  -  Stress echocardiography used for enrollment*

  -  No obstructive CAD on study coronary CT angiography (defined as no ≥50% stenosis in a
     major epicardial vessel)

  -  Ischemic symptoms (chest pain or other potential ischemic equivalent).

  -  Participant is willing to give written informed consent

  -  Age ≥ 21 years

Exclusion Criteria:

  -  Inability to comply with protocol

  -  Prior PCI or CABG