Have you or your loved ones been diagnosed with premenstrual syndrome?

You may be eligible to participate in a premenstrual syndrome clinical trial.

Have you or your loved ones been diagnosed with premenstrual syndrome? You may be eligible to participate in a premenstrual syndrome clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Premenstrual Syndrome Clinical Trial in Bethesda MD
NCT00001259 | Phase 1 | Interventional

Have you or your loved ones been diagnosed with premenstrual syndrome?

You may be eligible to participate in a premenstrual syndrome clinical trial.

Have you or your loved ones been diagnosed with premenstrual syndrome? You may be eligible to participate in a premenstrual syndrome clinical trial.

Completed

Female

18 - 45

Years old

This study has recruited 60 Participants

This study examines the effects of estrogen and progesterone on mood, the stress response, and brain function and behavior in women with premenstrual syndrome. Previously this study has demonstrated leuprolide acetate (Lupron (Registered Trademark)) to be an effective treatment for PMS. The current purpose of this study is to evaluate how low levels of estrogen and progesterone (that occur during treatment with leuprolide acetate) compare to menstrual cycle levels of estrogen and progesterone (given during individual months of hormone add-back) on a variety of physiologic measures (brain imaging, stress testing, etc.) in women with PMS. PMS is a condition characterized by changes in mood and behavior that occur during the second phase of the normal menstrual cycle (luteal phase). This study will investigate possible hormonal causes of PMS by temporarily stopping the menstrual cycle with leuprolide acetate and then giving, in sequence, the menstrual cycle hormones progesterone and estrogen. The results of these hormonal studies will be compared between women with PMS and healthy volunteers without PMS (see also protocol 92-M-0174). At study entry, participants will undergo a physical examination. Blood, urine, and pregnancy tests will be performed. Cognitive functioning and stress response will be evaluated during the study along with brain imaging and genetic studies.