Purpose and aims The general aim of this project is to improve the diagnostic methods for disease activity and identify predictive factors (clinical and radiographic factors, pro- and anti-inflammatory mediators in saliva and plasma) for temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA). The hypothesis is that self-reported pain and impaired jaw function together with clinical findings correlates well with radiological signs of jaw involvement. Null hypothesis: Self-reported pain, impaired jaw function and clinical findings do not correlate with radiological signs of jaw involvement. Study 1 The aim of this study is to investigate which findings from the patient history and from clinical examination that is of significance for diagnostics of TMJ involvement in patients with JIA both in a short- and long-term perspective. The patients will be followed-up during two years. They will undergo a clinical examination according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD; Dworkin and LeResche 1992) once a year and a telephone follow-up sixth months after the clinical examination. Further, the clinical findings from the orofacial regions will be compared to their general disease activity. Study 2 The aim of the second study is to correlate radiological findings and clinical findings in order to investigate any early radiological signs of disease activity and progression but also to compare the radiographic examination using conventional panoramic technique with computer tomography (CT).

Population

One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included.

Brief Title

Prediction of Temporomandibular Involvement in Juvenile Idiopathic Arthritis

Official Title

Prediction of Temporomandibular Involvement in Juvenile Idiopathic Arthritis

Brief Summary

Purpose and aims The general aim of this project is to improve the diagnostic methods for <br /> disease activity and identify predictive factors (clinical and radiographic factors, pro- and <br /> anti-inflammatory mediators in saliva and plasma) for temporomandibular joint (TMJ) <br /> involvement in juvenile idiopathic arthritis (JIA). <br /> <br /> The hypothesis is that self-reported pain and impaired jaw function together with clinical <br /> findings correlates well with radiological signs of jaw involvement. <br /> <br /> Null hypothesis: Self-reported pain, impaired jaw function and clinical findings do not <br /> correlate with radiological signs of jaw involvement. <br /> <br /> Study 1 The aim of this study is to investigate which findings from the patient history and <br /> from clinical examination that is of significance for diagnostics of TMJ involvement in <br /> patients with JIA both in a short- and long-term perspective. The patients will be <br /> followed-up during two years. They will undergo a clinical examination according to Research <br /> Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD; Dworkin and LeResche 1992) once <br /> a year and a telephone follow-up sixth months after the clinical examination. Further, the <br /> clinical findings from the orofacial regions will be compared to their general disease <br /> activity. <br /> <br /> Study 2 The aim of the second study is to correlate radiological findings and clinical <br /> findings in order to investigate any early radiological signs of disease activity and <br /> progression but also to compare the radiographic examination using conventional panoramic <br /> technique with computer tomography (CT).

Detailed Description

One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric
Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included.

Inclusion criteria are:

- age between 7 and 14 years

- a diagnosis of JIA according to the International League of Associations for
rheumatology

Exclusion criteria are:

- current malignancies

- TMJ surgery or trauma within two years

- recent intra-articular glucocorticoid injection in TMJ (within 1 month)

- other conditions or diseases than JIA that may cause orofacial pain. The parents of the
patients and/or the patients will give their verbal and written informed consent to
participate in the study according to the permission from the regional ethical committee
2011/2:1.

Clinical examination and follow-ups The patients will be examined clinically three times with
an interval of 12 months. The clinical examination will be performed according to the RDC-TMD
by calibrated investigators. Panoramic x-ray and CT scans will be performed at the inclusion
examination as well as at the end of the study after 24 months. Pharmacological treatment
will be recorded at every clinical examination and at telephone interviews. The patients will
also be examined by a pediatric rheumatologist regarding general disease activity according
to the Juvenile Arthritis Disease Activity Score 27 (JADAS-27), the Short Form (36) Health
Survey (SF-36), thrombocyte particle count, C-reactive protein and blood titer of rheumatoid
factor and anti-cyclic citrullinated peptides. Information from the examination by the
pediatric rheumatologist will be drawn from the Swedish national register for children with
JIA.

Telephone interview Six months after the first and second visit, a structured telephone
interview with the patients and/or their parents will be performed according to a
questionnaire. The objective is to estimate the degree of joint pain and functional
limitations in jaw function.

Radiological examination Conventional panoramic x-rays and bilateral TMJ images will be
obtained with the digital volume tomography (DVT, New Tom Model QR-DVT 9000, New Tom AG,
Marburg, Germany). The CT sections will be evaluated by a specialist in oral radiology for
presence of radiographic signs of cortical and subcortical erosions, flattening, sclerosis
and ramus height.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.