Are you healthy and looking to help advance medical science?

You may be eligible to participate in a developmental dyslexia clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a developmental dyslexia clinical study, and could be compensated for your time.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Developmental Dyslexia Clinical Trial in Zurich

NCT02217696 | Interventional

Are you healthy and looking to help advance medical science?

You may be eligible to participate in a developmental dyslexia clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a developmental dyslexia clinical study, and could be compensated for your time.

Recruiting

Male & Female

5 - 9

Years old

This study is looking to recruit 110 Participants

The long-term goal of this study is to improve prediction of poor reading outcome at preschool age by using a combination of behavioural and neuroimaging measures and to evaluate a specific computerized training program to support children with problems during reading acquisition.

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Details for the study

Brief Title

Prediction and Intervention in Developmental Dyslexia

Official Title

Neuronal Markers of Grapheme-phoneme Training Response for Prediction of Successful Reading Acquisition in Children at Familial Risk for Developmental Dyslexia

Brief Summary

The long-term goal of this study is to improve prediction of poor reading outcome at<br /> preschool age by using a combination of behavioural and neuroimaging measures and to evaluate<br /> a specific computerized training program to support children with problems during reading<br /> acquisition.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Primary

Changes in reading and spelling performance

Performance in normed reading and/or spelling (standardized tests) as a result of reading acquisition and training

Participants will be tested at three times for the duration of the cross-sectional intervention, an expected average of 8 months

Secondary

Developmental and training induced changes in functional brain activation and brain structure

Changes in activation/structure of core language network regions assessed by EEG and MRI during development, learning and training

Participants will be tested after an expected average of 8, 12 and 16 months

Secondary

Accuracy of prediction on reading performance outcome

Accuracy of prediction on reading performance (standardized tests) using behavioural and/or neuroimaging measures. Neuroimaging measures: EEG and MRI (functional activation, structural measures from white and/or grey matter, temporal information from event-related potential and/or frequency analyses)

Participants will be tested at T1 and on average 8 months later

Study Criteria

Inclusion Criteria for all groups:

  -  Healthy, native (CH-) German speaking subjects, with an estimated non-verbal
     intelligence quotient (IQ) >=80, without neurological and/or psychiatric disorder
     (except for attention deficit hyperactivity disorder, specific learning disorders,
     developmental language impairments)

  -  Additional criteria for subgroups:

  -  Recruitment of preschoolers (aged 5.5-7.5 years):

  -  Healthy children with increased risk for developmental dyslexia in their second year
     at kindergarten

  -  Recruitment of children in first grade (aged 6.5-8.5years):

  -  Children showing impairments in learning to read (first/second grade).

  -  Adults (aged 20-40 years):

  -  Healthy, normal reading

Exclusion Criteria for all groups:

  -  MRI contraindications

  -  No history of premature delivery and/or maternal reports of severe prenatal, perinatal
     or postnatal complications.