Study Criteria

Inclusion Criteria:

  1. must have experienced bladder pain, urinary urgency and urinary frequency, for at
     least 6 months prior to entry into the study

  2. Pain VAS ≥4

  3. O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and
     pain ≥2, and nocturia ≥ 2)

  4. PUF score ≥ 13

  5. cystoscopic record within 2 years

  6. Hunner ulcer lesion in cystoscopic finding

Exclusion Criteria:

  1. Scheduled for or use of intravesical therapy (eg, bladder distention,transurethral
     resection of bladder ulcer, instillation) during or within 6months prior to the study
     and use of pentosan polysulfate sodium within 1 months prior to the study

  2. Patients who are pregnancy or, childbearing age without no contraception

  3. Patients with voided volume <40 or, > 400ml

  4. Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no
     evidence of neoplastic tumor examination

  5. Patients with urine culture showing evidence of urinary tract infection 1month prior
     to the study

  6. Accompanied medical problem below

       -  Tuberculosis in urinary system

       -  Bladder cancer, urethral cancer, prostate cancer

       -  Recurrent cystitis

       -  Anatomical disorder

  7. Patients had prior surgery (eq, bladder augmentation, cystectomy

  8. Patients with neurologic disorder

  9. Patients with indwelling catheter or intermittent self-catheterization

 10. Patients with psychologic problem