Have you or your loved ones been diagnosed with acute renal failure?

You may be eligible to participate in a acute renal failure clinical trial.

Have you or your loved ones been diagnosed with acute renal failure? You may be eligible to participate in a acute renal failure clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Acute Renal Failure Clinical Trial in Washington DC
NCT01941823 | Observational
Asha Moudgil
Sponsored by
Asha Moudgil

Have you or your loved ones been diagnosed with acute renal failure?

You may be eligible to participate in a acute renal failure clinical trial.

Have you or your loved ones been diagnosed with acute renal failure? You may be eligible to participate in a acute renal failure clinical trial.

Completed

Male & Female

1 - 21

Years old

This study has recruited 29 Participants

Carnitine is essential for the transport of fatty acids into the mitochondria and energy production in different muscles, including the myocardium. It is also needed to protect myocyte cell membranes from oxidative damage by removing excess acyl carnitine groups. Patients receiving chronic intermittent hemodialysis (HD) are known to be at increased risk for carnitine deficiency as a result of its removal during the dialysis procedure, lack of endogenous synthesis by the kidney, and inadequate dietary intake. The carnitine status of children undergoing continuous renal replacement therapy (CRRT) has not been studied. Children undergoing CRRT in the intensive care unit (ICU) setting may be at increased risk for carnitine deficiency due to its continuous removal, lack of carnitine production by the kidney, and absence of carnitine intake (as majority of these children can not eat and there is no carnitine added to total parenteral nutrition (TPN). Carnitine deficiency may increase the risk of cardiac dysfunction in critically ill children. This is the first study to examine carnitine status in children undergoing CRRT. Standard echo as well as more sensitive speckle tracking echo will be used to evaluate the effect of carnitine deficiency on myocardial function.