Have you or your loved ones been diagnosed with end stage renal disease?

You may be eligible to participate in a end stage renal disease clinical trial.

Have you or your loved ones been diagnosed with end stage renal disease? You may be eligible to participate in a end stage renal disease clinical trial.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

End Stage Renal Disease Clinical Trial in Kansas City KS

NCT01883349 | Observational

Have you or your loved ones been diagnosed with end stage renal disease?

You may be eligible to participate in a end stage renal disease clinical trial.

Have you or your loved ones been diagnosed with end stage renal disease? You may be eligible to participate in a end stage renal disease clinical trial.

Recruiting

Male & Female

30 - 70

Years old

This study is looking to recruit 140 Participants

The purpose of this study is to understand cognitive impairment in end stage renal disease before and after a kidney transplant.

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Details for the study

Population

The study population will include patients from the renal transplant waiting list at University of Kansas Medical Center. They will be tested before renal transplant and 3 months after renal transplantation.

Brief Title

Cognitive Impairment and Imaging Correlates in End Stage Renal Disease

Official Title

Cognitive Impairment and Imaging Correlates in End Stage Renal Disease

Brief Summary

The purpose of this study is to understand cognitive impairment in end stage renal disease<br /> before and after a kidney transplant.

Detailed Description

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact
mechanisms are not clear, but patients with ESRD have more cerebral white matter changes.
Several studies have shown that cognitive function improves post-transplant, indicating that
there may be some reversibility in the process. This study will examine the correlation
between cognitive impairment and structural brain changes before and after renal
transplantation. We will also study the correlation of cognitive function with serum
inflammatory markers before and after transplant. These results will be compared to aged
matched healthy controls without kidney disease.

Treatments and/or Procedures

Kidney transplant

Kidney Transplant Surgery

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Primary

Change in Cognitive Function

Cognitive testing will be performed for assessment

Change from Baseline to 3 Months after Renal Transplant

Secondary

Change in brain MRI

Brain MRI will be performed before and after transplant

Change from Baseline to 3 Months after Renal Transplant

Study Criteria

Inclusion Criteria:

  -  Pre-transplant ESRD patients between the ages of 30 and 70 years who are listed for
     renal transplantation

  -  Able to sign pre-transplant consent on their own will

  -  Have english as their native language

Exclusion Criteria:

  -  Current use of antipsychotics or anti-epileptics

  -  Inability to read or write which will limit their ability to perform the cognitive
     tests

  -  Claustrophobia or inability to get MRI for other reasons

  -  Unable to sign consent