Are you healthy and looking to help advance medical science?

You may be eligible to participate in a croup clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a croup clinical study, and could be compensated for your time.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Croup Clinical Trial in Seoul

NCT01664507 | Phase 4 | Interventional

Are you healthy and looking to help advance medical science?

You may be eligible to participate in a croup clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a croup clinical study, and could be compensated for your time.

Recruiting

Male & Female

6 - 5

Years old

This study is looking to recruit 84 Participants

Croup is common illness presenting emergency department with dyspnea. The main treatment for croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized L-epinephrine is restricted that the study of comparision between racemic epinephrine and L-epinephrine. The investigators conducted this study to compare the effectiveness of low dose L-epinephrine with conventional dose L-epinephrine.

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Details for the study

Brief Title

The Effect and Safety of Low Dose Nebulized Epinephrine in Croup

Official Title

The Effect and Safety of Low Dose Nebulized Epinephrine in the Treatment of Croup

Brief Summary

Croup is common illness presenting emergency department with dyspnea. The main treatment for croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized L-epinephrine is restricted that the study of comparision between racemic epinephrine and L-epinephrine. The investigators conducted this study to compare the effectiveness of low dose L-epinephrine with conventional dose L-epinephrine.

Treatments and/or Procedures

Low dose epinephrine

low dose epineprhine : 0.1mg/kg + 0.9% normal saline

Conventional dose epinephrine

conventional dose epinephrine : 0.5mg/kg + 0.9% normal saline

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Secondary

rebound effect

the croup score is the same or over than the base line

180 minutes

Secondary

treatment failure

after additional nebulized epineprhine at 30 minutes, as the croup scrore is higher than baselin, the blinding is cleared.

30min after 2nd epinephrine nebulizer

Secondary

the side effect of epinephrine

Hypertension, tachycardia : more than 95th percentile for age Arrythmia Pallor Tremor

participants will be followed for the duration of ED stay

Study Criteria

Inclusion Criteria:

  -  croup children between 6 month and 5 years old

  -  Westley croup score between 3 and 11

Exclusion Criteria:

  -  underlying lung or heart disase

  -  contra indication to dexamethasone

  -  immune deficient state

  -  preterm birth

  -  previous intubation or apnea history