Advanced Cancers Trials
Featured Trial
A Phase 1 Study of DCC-2618: Systemic Mastocyto...
This clinical trial is a phase 1, open-label study designed to evaluate the safety, tolerability, and preliminary antitumor activity of DCC-2618, administered orally (PO), in adult patients with advanced malignancies, including Systemic Mastocytosis (SM) and other hematologic malignancies. DC...
Recruiting
Male & Female
18 Years +
Dehydration Clinical Trial
The purpose of this study is to assess palliative care physicians' attitudes, beliefs and practice patterns related to parenteral hydration at the end of life in Latin America and Spain. Objectives: 1. To assess palliative care physicians' attitudes, beliefs and practi...
Recruiting
Male & Female
18 Years +
Advanced Malignant Neoplasm Clinical Trial
This phase I trial studies the side effects and best dose of bevacizumab and temsirolimus alone or in combination with valproic acid or cetuximab in treating patients with a malignancy that has spread to other places in the body or other disease that is not cancerous. Monoclonal...
Recruiting
Male & Female
All ages
Advanced Cancers Clinical Trial
The goal of this clinical research study is to find the highest tolerable dose of the combination of vandetanib and everolimus that can be given to patients with advanced cancer. The effects of the study drugs at different dose levels and the safety of the study drugs will also ...
Recruiting
Male & Female
All ages
Advanced Cancers Clinical Trial
The goal of this clinical research study is to learn about the safety of siRNA-EphA2-DOPC when given to patients with advanced, recurrent cancer. Researchers also want to learn the highest tolerable dose of this drug that can be given. siRNA-EphA2-DOPC is designed to shut down ...
Recruiting
Male & Female
18 Years +
Advanced Malignant Solid Neoplasm Clinical Trial
This phase I trial studies the side effects and best dose of ipilimumab and imatinib mesylate in treating participants with solid tumors that have spread to other places in the body or cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab, may interfere with th...
Recruiting
Male & Female
15 Years +
Advanced Cancers Clinical Trial
The goal of this laboratory research study is to collect and analyze treatment, molecular profiling and biomarker data. The results of the data analysis will be used to better understand how to characterize tumors and identify therapies that may be tailored to individual patient...
Recruiting
Male & Female
All ages
Advanced Cancer Clinical Trial
The goal of this laboratory research study is to learn if using molecular information (matched therapy) or not using molecular information and having the study doctor choose the therapy based on your past experience are more effective ways to choose the best cancer treatment for...
Recruiting
Male & Female
18 Years +
Advanced Cancers Clinical Trial
The goal of this clinical research study is to learn if talazoparib can help to control advanced cancer in patients who have a specific type of alteration (a type of genetic change). The safety of this drug will also be studied. This is an investigational study. Talazoparib is ...
Recruiting
Male & Female
18 Years +
Advanced Cancer Clinical Trial
Objectives: Primary Objectives: To evaluate the anti-cancer activity of commercially available, targeted anti-cancer therapies used off-label for treatment in patients with advanced solid cancer with known genomic aberrations. Secondary Objectives: To deter...
Recruiting
Male & Female
18 Years +
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